Last update
3/26/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
USERS' SCORE
Good
Based on 2 Reviews
8.6
Supplement Facts
Serving Size: 1 Veggie Capsule
Amount Per Serving
%DV
Nattokinase (from fibrinase enzymes)
2,000 FU**
†
Top Medical Research Studies
8
This study examined whether nattokinase monascus supplements could effectively lower cholesterol levels in people facing dyslipidemia. In a randomized trial with 113 participants, we noted significant reductions in total cholesterol, LDL cholesterol, and similar lipid markers after 120 days of using the supplements compared to a placebo.
However, we didn't see any notable improvements in triglycerides, HDL cholesterol, or carotid intima-media thickness. Importantly, participants experienced no major side effects from the treatment. Overall, while nattokinase supplements showed promise for some cholesterol levels, they did not deliver significant changes in all examined lipid factors.
However, we didn't see any notable improvements in triglycerides, HDL cholesterol, or carotid intima-media thickness. Importantly, participants experienced no major side effects from the treatment. Overall, while nattokinase supplements showed promise for some cholesterol levels, they did not deliver significant changes in all examined lipid factors.
Read More
7
Nattokinase affects hemostatic factors
We explored how nattokinase supplementation affects cholesterol levels and related hemostatic factors in individuals with high cholesterol. In a study with 100 participants, we divided them into nattokinase and placebo groups to monitor their responses over eight weeks.
We found that while there were no significant differences in initial measurements, those taking nattokinase showed notable increases in collagen-epinephrine closure time and activated partial thromboplastin time. However, these results indicate effects on hemostatic factors rather than a direct benefit to cholesterol levels.
In summary, while nattokinase appeared effective at influencing certain blood measures, it did not significantly improve overall cholesterol management.
We found that while there were no significant differences in initial measurements, those taking nattokinase showed notable increases in collagen-epinephrine closure time and activated partial thromboplastin time. However, these results indicate effects on hemostatic factors rather than a direct benefit to cholesterol levels.
In summary, while nattokinase appeared effective at influencing certain blood measures, it did not significantly improve overall cholesterol management.
Read More
Most Useful Reviews
9
Normal blood pressure
2 people found this helpful
Nattokinase has improved my blood vessel metabolism. My blood pressure, previously at 140, is now normal after taking it consistently. I'm pleased with these results.
Read More
9
Comprehensive health benefits
1 people found this helpful
Nattokinase, derived from the Japanese dish natto, exhibits a strong fibrinolytic effect, enhancing blood fluidity and affecting overall bodily functioning. It’s considered an excellent alternative to aspirin for maintaining blood density, contributing to heart health, normalising blood circulation, and reducing high cholesterol. I recommend it, particularly for those needing to manage health conditions.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
- All Researches
8
This study examined whether nattokinase monascus supplements could effectively lower cholesterol levels in people facing dyslipidemia. In a randomized trial with 113 participants, we noted significant reductions in total cholesterol, LDL cholesterol, and similar lipid markers after 120 days of using the supplements compared to a placebo.
However, we didn't see any notable improvements in triglycerides, HDL cholesterol, or carotid intima-media thickness. Importantly, participants experienced no major side effects from the treatment. Overall, while nattokinase supplements showed promise for some cholesterol levels, they did not deliver significant changes in all examined lipid factors.
However, we didn't see any notable improvements in triglycerides, HDL cholesterol, or carotid intima-media thickness. Importantly, participants experienced no major side effects from the treatment. Overall, while nattokinase supplements showed promise for some cholesterol levels, they did not deliver significant changes in all examined lipid factors.
Read More
7
Nattokinase affects hemostatic factors
We explored how nattokinase supplementation affects cholesterol levels and related hemostatic factors in individuals with high cholesterol. In a study with 100 participants, we divided them into nattokinase and placebo groups to monitor their responses over eight weeks.
We found that while there were no significant differences in initial measurements, those taking nattokinase showed notable increases in collagen-epinephrine closure time and activated partial thromboplastin time. However, these results indicate effects on hemostatic factors rather than a direct benefit to cholesterol levels.
In summary, while nattokinase appeared effective at influencing certain blood measures, it did not significantly improve overall cholesterol management.
We found that while there were no significant differences in initial measurements, those taking nattokinase showed notable increases in collagen-epinephrine closure time and activated partial thromboplastin time. However, these results indicate effects on hemostatic factors rather than a direct benefit to cholesterol levels.
In summary, while nattokinase appeared effective at influencing certain blood measures, it did not significantly improve overall cholesterol management.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
9
Normal blood pressure
2 people found this helpful
Nattokinase has improved my blood vessel metabolism. My blood pressure, previously at 140, is now normal after taking it consistently. I'm pleased with these results.
Read More
9
Comprehensive health benefits
1 people found this helpful
Nattokinase, derived from the Japanese dish natto, exhibits a strong fibrinolytic effect, enhancing blood fluidity and affecting overall bodily functioning. It’s considered an excellent alternative to aspirin for maintaining blood density, contributing to heart health, normalising blood circulation, and reducing high cholesterol. I recommend it, particularly for those needing to manage health conditions.
Read More
Frequently Asked Questions
8
This study examined whether nattokinase monascus supplements could effectively lower cholesterol levels in people facing dyslipidemia. In a randomized trial with 113 participants, we noted significant reductions in total cholesterol, LDL cholesterol, and similar lipid markers after 120 days of using the supplements compared to a placebo.
However, we didn't see any notable improvements in triglycerides, HDL cholesterol, or carotid intima-media thickness. Importantly, participants experienced no major side effects from the treatment. Overall, while nattokinase supplements showed promise for some cholesterol levels, they did not deliver significant changes in all examined lipid factors.
However, we didn't see any notable improvements in triglycerides, HDL cholesterol, or carotid intima-media thickness. Importantly, participants experienced no major side effects from the treatment. Overall, while nattokinase supplements showed promise for some cholesterol levels, they did not deliver significant changes in all examined lipid factors.
7
Nattokinase affects hemostatic factors
We explored how nattokinase supplementation affects cholesterol levels and related hemostatic factors in individuals with high cholesterol. In a study with 100 participants, we divided them into nattokinase and placebo groups to monitor their responses over eight weeks.
We found that while there were no significant differences in initial measurements, those taking nattokinase showed notable increases in collagen-epinephrine closure time and activated partial thromboplastin time. However, these results indicate effects on hemostatic factors rather than a direct benefit to cholesterol levels.
In summary, while nattokinase appeared effective at influencing certain blood measures, it did not significantly improve overall cholesterol management.
We found that while there were no significant differences in initial measurements, those taking nattokinase showed notable increases in collagen-epinephrine closure time and activated partial thromboplastin time. However, these results indicate effects on hemostatic factors rather than a direct benefit to cholesterol levels.
In summary, while nattokinase appeared effective at influencing certain blood measures, it did not significantly improve overall cholesterol management.
References
- Liu X, Zeng X, Mahe J, Guo K, He P, et al. The Effect of Nattokinase-Monascus Supplements on Dyslipidemia: A Four-Month Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Nutrients. 2023;15. 10.3390/nu15194239
- Yoo HJ, Kim M, Kim M, Lee A, Jin C, et al. The effects of nattokinase supplementation on collagen-epinephrine closure time, prothrombin time and activated partial thromboplastin time in nondiabetic and hypercholesterolemic subjects. Food Funct. 2019;10:2888. 10.1039/c8fo02324g
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