Overview

SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
USERS' SCORE
Good
Based on 159 Reviews
8.1
Supplement Facts
Serving Size: 1 Veggie Capsule
Amount Per Serving
%DV
Nattokinase (from fibrinase enzymes)
2,000 FU**

Top Medical Research Studies

8
Nattokinase shows mixed cholesterol benefits
This study examined whether nattokinase monascus supplements could effectively lower cholesterol levels in people facing dyslipidemia. In a randomized trial with 113 participants, we noted significant reductions in total cholesterol, LDL cholesterol, and similar lipid markers after 120 days of using the supplements compared to a placebo.

However, we didn't see any notable improvements in triglycerides, HDL cholesterol, or carotid intima-media thickness. Importantly, participants experienced no major side effects from the treatment. Overall, while nattokinase supplements showed promise for some cholesterol levels, they did not deliver significant changes in all examined lipid factors.
Read More
7
Nattokinase affects hemostatic factors
We explored how nattokinase supplementation affects cholesterol levels and related hemostatic factors in individuals with high cholesterol. In a study with 100 participants, we divided them into nattokinase and placebo groups to monitor their responses over eight weeks.

We found that while there were no significant differences in initial measurements, those taking nattokinase showed notable increases in collagen-epinephrine closure time and activated partial thromboplastin time. However, these results indicate effects on hemostatic factors rather than a direct benefit to cholesterol levels.

In summary, while nattokinase appeared effective at influencing certain blood measures, it did not significantly improve overall cholesterol management.
Read More

Most Useful Reviews

9
Thinned blood
394 people found this helpful
My father has had thick blood due to high cholesterol and blood clots for years. After developing diabetes post-Covid, he faced more challenges. I ordered this highly rated Nattokinase supplement for him, and within a month, he noticed his blood becoming much thinner. His blood pressure is also normalising after a long struggle with it. He is extremely pleased with the results and highly recommends this product.
Read More
9
Cardiovascular support
190 people found this helpful
Nattokinase is an excellent enzyme for dissolving blood clots and is widely recognised in various countries. It holds great promise for thrombolytic therapy and supports overall cardiovascular health. I am pleased with the quality and effectiveness of "Doctor's Best" Nattokinase; it has exceeded my expectations.
Read More
9
Pressure regulation
188 people found this helpful
I use nattokinase to improve my blood fluidity, addressing my thick blood caused by high cholesterol, which elevates my pressure and clot risk. I take it in the evening and on an empty stomach in the morning. Since using it regularly, I have forgotten about my blood pressure issues.
Read More

Medical Researches

SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
  • All Researches
8
Nattokinase shows mixed cholesterol benefits
This study examined whether nattokinase monascus supplements could effectively lower cholesterol levels in people facing dyslipidemia. In a randomized trial with 113 participants, we noted significant reductions in total cholesterol, LDL cholesterol, and similar lipid markers after 120 days of using the supplements compared to a placebo.

However, we didn't see any notable improvements in triglycerides, HDL cholesterol, or carotid intima-media thickness. Importantly, participants experienced no major side effects from the treatment. Overall, while nattokinase supplements showed promise for some cholesterol levels, they did not deliver significant changes in all examined lipid factors.
Read More
7
Nattokinase affects hemostatic factors
We explored how nattokinase supplementation affects cholesterol levels and related hemostatic factors in individuals with high cholesterol. In a study with 100 participants, we divided them into nattokinase and placebo groups to monitor their responses over eight weeks.

We found that while there were no significant differences in initial measurements, those taking nattokinase showed notable increases in collagen-epinephrine closure time and activated partial thromboplastin time. However, these results indicate effects on hemostatic factors rather than a direct benefit to cholesterol levels.

In summary, while nattokinase appeared effective at influencing certain blood measures, it did not significantly improve overall cholesterol management.
Read More

User Reviews

USERS' SCORE
Good
Based on 159 Reviews
8.1
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9
Thinned blood
394 people found this helpful
My father has had thick blood due to high cholesterol and blood clots for years. After developing diabetes post-Covid, he faced more challenges. I ordered this highly rated Nattokinase supplement for him, and within a month, he noticed his blood becoming much thinner. His blood pressure is also normalising after a long struggle with it. He is extremely pleased with the results and highly recommends this product.
Read More
9
Cardiovascular support
190 people found this helpful
Nattokinase is an excellent enzyme for dissolving blood clots and is widely recognised in various countries. It holds great promise for thrombolytic therapy and supports overall cardiovascular health. I am pleased with the quality and effectiveness of "Doctor's Best" Nattokinase; it has exceeded my expectations.
Read More
9
Pressure regulation
188 people found this helpful
I use nattokinase to improve my blood fluidity, addressing my thick blood caused by high cholesterol, which elevates my pressure and clot risk. I take it in the evening and on an empty stomach in the morning. Since using it regularly, I have forgotten about my blood pressure issues.
Read More
9
Promotes heart health
94 people found this helpful
Nattokinase is vital for blood flow, boasting high fibrinolytic activity and beneficial effects such as reducing high cholesterol and promoting heart health. It also helps alleviate varicose veins and headaches.
Read More
9
Normalises blood pressure
86 people found this helpful
My father has had thick blood due to high cholesterol and developed diabetes post-COVID. After trying various blood thinners, this nattokinase supplement worked excellently, normalising his blood pressure efficiently within a month.
Read More

Frequently Asked Questions

9
Thinned blood
394 people found this helpful
My father has had thick blood due to high cholesterol and blood clots for years. After developing diabetes post-Covid, he faced more challenges. I ordered this highly rated Nattokinase supplement for him, and within a month, he noticed his blood becoming much thinner. His blood pressure is also normalising after a long struggle with it. He is extremely pleased with the results and highly recommends this product.
9
Lowered blood pressure
9 people found this helpful
Taking Nattokinase alongside serrapeptase reduced my blood pressure dramatically after years of being high. I stopped my prescription medication four weeks ago, and my blood pressure is now normal, thanks to this supplement.
9
Family health boost
24 people found this helpful
Nattokinase has been a long-term investment in our health, particularly for addressing high cholesterol. The gentle blood-thinning effects help prevent the formation of clots and alleviate symptoms of migraines. We have noticed its cumulative impact, especially for my elderly parents, who now use it regularly. By prioritising our vascular health, we aim to diminish the risk of strokes or heart attacks in our family.
9
Lowered blood pressure
8 people found this helpful
I was hesitant to take prescription drugs for high blood pressure. However, after trying Nattokinase, I was amazed by the 50-point drop! Remarkably, there were no side effects at all.
9
Quick results
17 people found this helpful
Nattokinase has proven incredible for me; it dissolved a significant blood clot in my leg within days, astonishing my doctor. He was amazed that such clots typically take weeks to resolve. I've been taking this in high doses and intend to continue its use for better cardiovascular health.
9
Significant health improvements
9 people found this helpful
After researching Nattokinase for my parents, who suffer from high cholesterol and blood pressure, we noticed significant improvements after just a month of use. Their test results returned to normal levels, making me very satisfied with the outcome.
9
Pressure regulation
188 people found this helpful
I use nattokinase to improve my blood fluidity, addressing my thick blood caused by high cholesterol, which elevates my pressure and clot risk. I take it in the evening and on an empty stomach in the morning. Since using it regularly, I have forgotten about my blood pressure issues.
9
Positive blood results
7 people found this helpful
Nattokinase has worked wonders for me as an alternative to statins for my high cholesterol. I’ve been taking it for a month, and my blood work results were promising. The easy-to-swallow capsules are taken on an empty stomach.
9
Aspirin alternative
47 people found this helpful
Nattokinase is a potent fibrinolytic enzyme, absorbed into the bloodstream to enhance fluidity. It’s recognised for its effectiveness in preventing and treating cardiovascular issues. It comes from Natto, a specific strain of bacteria enhances its benefits. Regular consumption of Nattokinase could reduce blood viscosity and is a safer alternative to aspirin, with no side effects detected over 20 years.
8
Nattokinase shows mixed cholesterol benefits
This study examined whether nattokinase monascus supplements could effectively lower cholesterol levels in people facing dyslipidemia. In a randomized trial with 113 participants, we noted significant reductions in total cholesterol, LDL cholesterol, and similar lipid markers after 120 days of using the supplements compared to a placebo.

However, we didn't see any notable improvements in triglycerides, HDL cholesterol, or carotid intima-media thickness. Importantly, participants experienced no major side effects from the treatment. Overall, while nattokinase supplements showed promise for some cholesterol levels, they did not deliver significant changes in all examined lipid factors.
7
Nattokinase affects hemostatic factors
We explored how nattokinase supplementation affects cholesterol levels and related hemostatic factors in individuals with high cholesterol. In a study with 100 participants, we divided them into nattokinase and placebo groups to monitor their responses over eight weeks.

We found that while there were no significant differences in initial measurements, those taking nattokinase showed notable increases in collagen-epinephrine closure time and activated partial thromboplastin time. However, these results indicate effects on hemostatic factors rather than a direct benefit to cholesterol levels.

In summary, while nattokinase appeared effective at influencing certain blood measures, it did not significantly improve overall cholesterol management.

References

  1. Liu X, Zeng X, Mahe J, Guo K, He P, et al. The Effect of Nattokinase-Monascus Supplements on Dyslipidemia: A Four-Month Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Nutrients. 2023;15. doi:10.3390/nu15194239
  2. Yoo HJ, Kim M, Kim M, Lee A, Jin C, et al. The effects of nattokinase supplementation on collagen-epinephrine closure time, prothrombin time and activated partial thromboplastin time in nondiabetic and hypercholesterolemic subjects. Food Funct. 2019;10:2888. doi:10.1039/c8fo02324g
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